Citation
E. Bezard et al., Effect of the alpha 2 adrenoreceptor antagonist, idazoxan, on motor disabilities in MPTP-treated monkey, PROG NEUR-P, 23(7), 1999, pp. 1237-1246
Citations number
33
Categorie Soggetti
Neurosciences & Behavoir
Journal title
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
ISSN journal
02785846
→ ACNP
Volume
23
Issue
7
Year of publication
1999
Pages
1237 - 1246
Database
ISI
SICI code
0278-5846(199910)23:7<1237:EOTA2A>2.0.ZU;2-X
Abstract
1. The motor effect of the alpha 2 adrenoreceptor antagonist, idazoxan, was
compared to that of L-dopa in MPTP-treated monkeys.
2. Idazoxan 2.0 mg/kg improved parkinsonian motor abnormalities which was c
omparable to the effects of a minimal effective dose of L-dopa.
3. At 2.0 and 5.0 mg/kg, the parkinsonian rigidity was the item most freque
ntly alleviated by idazoxan (respectively 63.6% and 68.2%).
4. These findings provide support for the therapeutic utility of alpha 2 an
tagonists in the treatment of Parkinson's disease.