Effects of selegiline pretreatment on response to experimental cocaine administration

Several medications have been reported to alter the subjective effects of e xperimentally administered cocaine. We studied the effects of selegiline, a monoamine oxidase B inhibitor, on the subjective effects of experimentally administered cocaine in chronically cocaine-dependent subjects. Eight subj ects completed a protocol that involved repeated administrations of cocaine before and after treatment with selegiline, given in extended release form , 10 mg per day, Four days of treatment with selegiline was associated with decreased self-reported 'high' and 'stimulated' feelings after cocaine adm inistration, measured as the area under the curve. Changes in other subject ive effects were less pronounced. Selegiline pretreatment had minimal effec ts on the cardiovascular responses to cocaine administration. (C) 1999 Else vier Science Ireland Ltd. All rights reserved.