Serotonin-2A receptor polymorphism (102T/C) in mood disorders

Authors
Tsai, SJ Hong, CJ Hsu, CC Cheng, CY Liao, WY Song, HL Lai, HC
Citation
Sj. Tsai et al., Serotonin-2A receptor polymorphism (102T/C) in mood disorders, PSYCHIAT R, 87(2-3), 1999, pp. 233-237
Citations number
14
Categorie Soggetti
Psychiatry,"Neurosciences & Behavoir
Journal title
PSYCHIATRY RESEARCH
ISSN journal
01651781 → ACNP
Volume
87
Issue
2-3
Year of publication
1999
Pages
233 - 237
Database
ISI
SICI code
0165-1781(19991011)87:2-3<233:SRP(IM>2.0.ZU;2-8
Abstract
Serotonergic dysfunction has been implicated in mood disorders and suicidal behaviors. This study examined the association between a serotonin-2A (5HT (2A)) receptor gene polymorphism (102T/C) and mood disorders. The genotype and allele frequencies did not differ between patients with mood disorders and control subjects. Furthermore, the 102T/C polymorphism was not found to be associated with suicidal history in mood disorder patients. Our results suggest that this polymorphism is unlikely to play a role in the genetic s usceptibility to mood disorders. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.