Thrombopenia and acute renal failure following intravenous streptokinase. The role of steroid therapy

Proteinuria is common after streptokinase treatment. An immunological mecha nism in the renal glomerulus has been suggested to explain this side effect . However, thrombopenia and acute renal failure streptokinase induced are u ncommon. We present a case of thrombopenia and acute renal failure after st reptokinase administration for myocardial infarction that improved with ste roid therapy. Rie discuss the probable pathophysiology of these adverse eff ects of streptokinase and the potencial usefulness of steroids in its preve ntion and treatment.