Co-distribution of sensory gating and impaired niacin flush response in the parents of schizophrenics

Authors
Citation
Mc. Waldo, Co-distribution of sensory gating and impaired niacin flush response in the parents of schizophrenics, SCHIZOPHR R, 40(1), 1999, pp. 49-53
Citations number
34
Categorie Soggetti
Psychiatry,"Neurosciences & Behavoir
Journal title
SCHIZOPHRENIA RESEARCH
ISSN journal
09209964 → ACNP
Volume
40
Issue
1
Year of publication
1999
Pages
49 - 53
Database
ISI
SICI code
0920-9964(19991109)40:1<49:COSGAI>2.0.ZU;2-E
Abstract
Complex illnesses may result from the interaction or addition of multiple f actors. We examined the familial co-distribution of two abnormalities commo n in schizophrenia: impaired auditory sensory gating and impaired flush res ponse to niacin. In ten families, the obligate carrier parent had sensory-g ating deficits, while eight of the ten parents without a family history of schizophrenia had impaired flush response. No parents had both deficits. Th e data are consistent with a theory suggesting the interaction of these two factors in some cases of schizophrenia. (C) 1999 Elsevier Science B.V. All rights reserved.