Discrete-event models of mixed-phenotype Plasmodium falciparum malaria

We extend our basic discrete-event model of Plasmodium falciparum malaria t o encompass circumstances in which multiple phenotypic variants of the para site circulate within interacting human and mosquito populations, and we co mpare a version in which variants behave independently to one in which they interact through shared host immune responses. Relative to the standard hy pothesis of statistical independence, frequencies of mixed-phenotype infect ion in humans were as expected in the independent-immunity version anf much less than expected in the cross-immunity version; in both versions, howeve r, such frequencies in mosquitoes were much greater than expected.