Cf. Ryan et al., Mandibular advancement oral appliance therapy for obstructive sleep apnoea: effect on awake calibre of the velopharynx, THORAX, 54(11), 1999, pp. 972-977
Background-The mechanisms of action of oral appliance therapy in obstructiv
e sleep apnoea are poorly understood. Videoendoscopy of the upper airway wa
s used during wakefulness to examine whether the changes in pharyngeal dime
nsions produced by a mandibular advancement oral appliance are related to t
he improvement in the severity of obstructive sleep apnoea.
Methods-Fifteen patients with mild to moderate obstructive sleep apnoea (me
dian (range) apnoea index (AI) 4(0-38)/h, apnoea-hypopnoea index (AHI) 28(9
-45)/h) underwent overnight polysomnography and imaging of the upper airway
before and after insertion of the oral appliance. Images were obtained in
the hypopharynx, oropharynx, and velopharynx at end tidal expiration during
quiet nasal breathing in the supine position. The cross sectional area and
diameters of the upper airway were measured using image processing softwar
e with an intraluminal catheter as a linear calibration.
Results-AI decreased to a median (range) value of 0 (0-6)/h (p<0.01) and AH
I to 8 (1-28)/h (p<0.001) following insertion of the oral appliance. The me
dian (95% confidence interval) cross sectional area of the upper airway inc
reased by 18% (3 to 35) (p<0.02) in the hypopharynx and by 25% (11 to 69) (
p<0.005) in the velopharynx, but not significantly in the oropharynx. Altho
ugh in general the shape of the pharynx did not change following insertion
of the oral appliance, the lateral diameter of the velopharynx increased to
a greater extent than the anteroposterior diameter. Following insertion of
the oral appliance the reduction in AHI was related to the increase in cro
ss sectional area of the velopharynx (p = 0.01).
Conclusions-A mandibular advancement oral appliance increases the cross sec
tional area of the upper airway during wakefulness, particularly in the vel
opharynx. Assuming this effect on upper airway calibre is not eliminated by
sleep, mandibular advancement oral appliances may reduce the severity of o
bstructive sleep apnoea by maintaining patency of the velopharynx, particul
arly in its lateral dimension.