Recombinant human growth hormone improves the fat redistribution syndrome (lipodystrophy) in patients with HIV

Objective: To determine the efficacy of recombinant human growth hormone (r hGH) in the treatment of the fat redistribution syndrome (FRS) in patients with HIV. Design: A prospective, open-label study. Setting: An urban, university-affiliated Infectious Disease Clinic. Patients: Ten HIV-infected patients (seven men, three women) with FRS. Interventions: Treatment with 6 mg of rhGH a day, subcutaneously for 12 wee ks. Main outcome measures: Body mass index (BMI), body composition by bioelectr ical impedance analysis (BIA), body composition by anthropometrics (includi ng waist/hip ratio), buffalo hump. Results: The mean age was 41.7 years, the CD4 cell count was 247, and the H IV RNA was 95 735 copies/ml; 50% had undetectable viral RNA. The BMI was si gnificantly increased from baseline to the end of treatment with growth hor mone (25.3-26.9 kg/m(2); P < 0.04); the waist/hip ratio significantly decre ased from baseline levels, after treatment with growth hormone (1.03-0.9; P < 0.04); mid-thigh circumference increased significantly when baseline was compared with measures after treatment (49.1-51.8 cm; P < 0.03). One patie nt had to discontinue therapy because of hyperglycemia. Conclusion: Short-term treatment with rhGH improved the alterations in body shape that occur with FRS in HIV-infected patients. Waist/hip ratios and m id-thigh circumference are useful measures to follow alterations in body sh ape in FRS. (C) 1999 Lippincott Williams & Wilkins.