Obesity at the age of 50 y in men and women exposed to famine prenatally

Background: It was shown that men who were conceived during the Dutch famin e of 1944-1945 had higher rates of obesity at age 19 y than those conceived before or after it. Objective: Our objective was to study the effects of prenatal exposure to t he Dutch famine on obesity in women and men at age 50 y, Design: We measured the body size of 741 people born at term between Novemb er 1943 and February 1947 in Amsterdam. We compared people exposed to famin e in late, mid, or early gestation (exposed participants) with those born b efore or conceived after the famine period (nonexposed participants). Results: The body mass index (BMI; in kg/m(2)) of 50-y-old women exposed to famine in early gestation was significantly higher by 7.4% (95% CI, 0.7%, 14.5%) than that of nonexposed women. BMI did not differ significantly in w omen exposed in mid gestation (-2.1%; -7.0%, 3.1%) or in late gestation (-1 .3%; -6.3%, 3.9%). In 50-y-old men, BMI was not significantly affected by e xposure to famine during any stage of gestation: BMI differed by 0.4% (-3.5 %, 4.5%) in men exposed to famine in late gestation, by -1.2% (-5.5%, 3.3%) in those exposed in mid gestation, and by 0.5% (-4.6%, 6.0%) in those expo sed in early gestation compared with nonexposed men. Conclusions: Maternal malnutrition during early gestation was associated wi th higher BMI and waist circumference in 50-y-old women but nor in men. The se findings suggest that pertubations of central endocrine regulatory syste ms established in early gestation may contribute to the development of abdo minal obesity in later life.