Laboratory testing, diagnosis, and management of von Willebrand disease - Current practice in Australasia

We report an evaluation of current laboratory and clinical practice for the diagnosis and management of von Willebrand disease (VWD) for a wide geogra phic area including Australia, New Zealand, and parts of Southeast Asia. Th is assessment has been undertaken in conjunction with the RCPA Quality Assu rance Program (QAP) in Haematology. This external OAP currently comprises a round 550 participating laboratories, of which some 450 perform coagulation testing, and from which 32 laboratories were identified to be actively inv olved in testing for VWD. These laboratories were targeted and their curren t laboratory and clinical practice evaluated by using various questionnaire s. Our overall findings indicate a wide variation in laboratory test practi ce for VWD-based investigations. There was considerable variation among lab oratories in the rests and test methods used, the control and calibration m aterial used, the reported test reference intervals and units used, and the composite test panels used to diagnose VWD. However; substantial consensus in the clinical evaluation process, as undertaken by hematologists, also w as identified Despite the observed variations most laboratory professionals seemed to understand the complexities involved in the diagnosis and subcla ssification of VWD, and the laboratories can provide an effective diagnosti c service.