Disseminated aspergillosis involving the brain distribution and imaging characteristics

BACKGROUND AND PURPOSE: Systemic invasive aspergillosis involves the brain through hematogenous dissemination. A retrospective review of 18 patients w ith aspergillosis involving the brain was performed in order to present ima ging findings and thereby broaden the understanding of the distribution and imaging characteristics of brain Aspergillus infection and to facilitate i ts early diagnosis. METHODS: The neuroimaging studies of 17 biopsy- or autopsy-proved cases and one clinically diagnosed case were examined retrospectively by two neurora diologists, The studies were evaluated for anatomic distribution of lesions , signal characteristics of lesions, enhancement, hemorrhage, and progressi on on serial studies (when performed), Medical records, biopsy reports, and autopsy findings were reviewed. RESULTS: Thirteen of 18 patients had involvement of the basal nuclei and/or thalami, Nine of the 10 patients with lesions at the corticomedullary junc tion also had lesions in the basal nuclei or thalami, Callosal lesions were seen in seven patients, Progression of lesion number and size was seen in all 11 patients in whom serial studies had been performed, Enhancement was minimal or absent in most cases, There was gross hemorrhage in eight of the 18, and definite ring-enhancement in three. CONCLUSION: Among our cases, lesions in perforating artery territories were more common than those at the corticomedullary junction, Ring enhancement and gross hemorrhage may be present, but are not necessary for the prospect ive diagnosis.