Tsm. Tsang et al., INCIDENCE AND IMPACT ON OUTCOME OF STREPTOKINASE ALLERGY IN THE GUSTO-I TRIAL, The American journal of cardiology, 79(9), 1997, pp. 1232
We evaluated allergic reactions in 20,201 patients randomized to the s
treptokinase arms of The Global Utilization of Streptokinase and t-PA
(Tissue Plasminogen Activator) in Occluded Coronary Arteries (GUSTO-I)
trial, and tested the hypothesis that patients with streptokinase all
ergy would exhibit higher mortality. After adjusting for baseline vari
ables and time of death, we found comparable coronary patency, left ve
ntricular function, mortality, and bleeding complications between pati
ents with versus those without streptokinase allergy.