We report the occurrence of a refractory infection caused by the "rapidly g
rowing" nontuberculous mycobacterium, Mycobacterium fortuitum, after incisi
onal hernia repair using synthetic mesh. The patient had previously undergo
ne three herniorrhaphies incorporating polypropylene mesh. Multiple surgica
l debridements were required, along with complete removal of all the mesh,
to eradicate the infection. Prolonged antimicrobial therapy with sulfametho
xazole, an agent active against the patient's isolate, was also used. Altho
ugh this atypical mycobacterium has been reported to cause a variety of inf
ections, including many types of periprosthetic infections, this case repre
sents successful treatment of M. fortuitum infecting abdominal wall mesh.