We measured skeletal muscle mass and peak oxygen consumption (VO2) in
13 cachectic heart failure patients, 14 noncachectic patients, and in
52 healthy controls to examine skeletal muscle atrophy and its relatio
n to low peak VO2 in heart failure patients. Our results show that ske
letal muscle atrophy is associated with prior weight loss and is relat
ed to low peak VO, in heart failure patients.