K. Tohyama et al., AORTIC-VALVE PROLAPSE AND AORTIC REGURGITATION ASSOCIATED WITH SUBPULMONIC VENTRICULAR SEPTAL-DEFECT, The American journal of cardiology, 79(9), 1997, pp. 1285
The natural development of aortic valve deformity was studied in 315 p
atients with subpulmonic ventricular septal defect. The patients with
early development of aortic regurgitation had a pulmonary-to-systemic
flow ratio of >1.5, normal right ventricular pressure, and severe aort
ic regurgitation.