J. Rehbock et al., BRADYKININ STIMULATES INTERLEUKIN-6 AND INTERLEUKIN-8 SECRETION OF HUMAN DECIDUA DERIVED CELLS, British journal of obstetrics and gynaecology, 104(4), 1997, pp. 495-499
Cytokines are known to participate in the process of parturition withi
n a paracrine network in fetal membranes. Bradykinin can also contribu
te to this process, increasing the release of eicosanoids from decidua
cells. In this study, we present evidence for a cross-link between br
adykinin and the cytokines. Short and long term cultures of human deci
dua cells were incubated for 4 h and 24 h with and without bradykinin.
IL-6 and IL-8 were determined in the supernatants by ELISA. Results s
how a large interindividual variability in the basal secretion of IL-6
and IL-8 and a clear increase in the secretion of both ILs in respons
e to bradykinin. By this amplifying effect on cytokine secretion, brad
ykinin can initiate local and systemic effects of amniochorionitis.