BRADYKININ STIMULATES INTERLEUKIN-6 AND INTERLEUKIN-8 SECRETION OF HUMAN DECIDUA DERIVED CELLS

Cytokines are known to participate in the process of parturition withi n a paracrine network in fetal membranes. Bradykinin can also contribu te to this process, increasing the release of eicosanoids from decidua cells. In this study, we present evidence for a cross-link between br adykinin and the cytokines. Short and long term cultures of human deci dua cells were incubated for 4 h and 24 h with and without bradykinin. IL-6 and IL-8 were determined in the supernatants by ELISA. Results s how a large interindividual variability in the basal secretion of IL-6 and IL-8 and a clear increase in the secretion of both ILs in respons e to bradykinin. By this amplifying effect on cytokine secretion, brad ykinin can initiate local and systemic effects of amniochorionitis.