M. Kocabatmaz et al., EFFECT OF GARLIC OIL ON PLASMA, ERYTHROCYTE AND ERYTHROCYTE-MEMBRANE TOTAL LIPIDS, CHOLESTEROL AND PHOSPHOLIPID LEVELS OF HYPERCHOLESTEROLEMIC DOGS, Medical science research, 25(4), 1997, pp. 265-267
30 Adult mongrel dogs were assigned randomly to three groups with 10 a
nimals each. Group 1 served as normal controls and were fed a standard
control diet for 9 weeks. Group 2 animals received the control diet p
lus 0.5% cholesterol powder for 9 weeks and Group 3 animals were fed t
he control diet plus 0.5% cholesterol for 6 weeks and received the con
trol diet containing 5% cholesterol plus garlic oil at the rate of 20
mg kg(-1) body weight daily for the last 3 weeks of the experiment. Th
e cholesterol-rich diet significantly increased plasma total lipid, to
tal cholesterol and phospholipid levels in Groups 2 and 3 as compared
with normally fed dogs' pre-experiment values of Groups 2 and 3 (p < 0
.05). Also, erythrocyte and erythrocyte membrane total lipid, choleste
rol and phospholipid levels were significantly elevated by the cholest
erol-rich diet in Groups 2 and 3 animals (p < 0.05). After 3 weeks of
garlic oil administration in Group 3, plasma, erythrocyte and erythroc
yte membrane total lipid, total cholesterol and phospholipid levels si
gnificantly decreased (p < 0.05) as compared to those in animals recei
ving cholesterol diet alone. However, their levels were still higher t
han in this group before the experiment and than those in control dogs
. A comparison between Groups 2 and 3 shows that garlic oil had a redu
cing effect on plasma and erythrocytes and their membrane lipids, and
prevents the alimentary hyperlipidaemia.