Cardiovascular diseases, particularly coronary heart disease (CHD) and myoc
ardial infarction (MI), are among the leading causes for morbidity and mort
ality in industrialized countries [2, 77]. During the past decades, various
clinical or lifestyle risk factors for myocardial infarction such as hyper
lipidemia, hypertension, obesity, lack of physical exercise and smoking hav
e been identified. However, it is also recognized that these well-documente
d risk factors do not sufficiently account for all new cases of myocardial
infarction [77]. Many patients with myocardial infarction have only a borde
rline risk profile or even lack known risk factors. The question arises: Wh
at additional risk factors may play a role in the etiology of atheroscleros
is and ischemic heart disease? (C) 1999 editions scientifiques et medicales
Elsevier SAS.