Superiority of the carbamoylmethyl ester as an acyl donor for the protease-catalyzed kinetically controlled peptide synthesis in organic media: Application to segment condensations

Authors
Miyazawa, T Ensatsu, E Tanaka, K Yanagihara, R Yamada, T
Citation
T. Miyazawa et al., Superiority of the carbamoylmethyl ester as an acyl donor for the protease-catalyzed kinetically controlled peptide synthesis in organic media: Application to segment condensations, CHEM LETT, (10), 1999, pp. 1013-1014
Citations number
6
Categorie Soggetti
Chemistry
Journal title
CHEMISTRY LETTERS
ISSN journal
03667022 → ACNP
Issue
10
Year of publication
1999
Pages
1013 - 1014
Database
ISI
SICI code
0366-7022(199910):10<1013:SOTCEA>2.0.ZU;2-D
Abstract
The superiority of the carbamoylmethyl ester as an acyl donor for the alpha -chymotrypsin-catalyzed kinetically controlled peptide synthesis was demons trated in several segment condensations carried out in organic media with l ow water content. Then this approach was successfully applied to the constr uction of the Leu-enkephalin sequence via the 4 + 1 segment condensation.