Non-covalent combinations of lanthanide(III) ion and two DNA oligomers forsequence-selective RNA scission

Authors
Kuzuya, A Akai, M Komiyama, M
Citation
A. Kuzuya et al., Non-covalent combinations of lanthanide(III) ion and two DNA oligomers forsequence-selective RNA scission, CHEM LETT, (10), 1999, pp. 1035-1036
Citations number
17
Categorie Soggetti
Chemistry
Journal title
CHEMISTRY LETTERS
ISSN journal
03667022 → ACNP
Issue
10
Year of publication
1999
Pages
1035 - 1036
Database
ISI
SICI code
0366-7022(199910):10<1035:NCOLIA>2.0.ZU;2-K
Abstract
By using non-covalent combinations of Lu(III) ion and two DNA oligomers, ea ch of which is complementary with a part of RNA, the RNA is sequence-select ively hydrolyzed. When all the ribonucleotides, except for three consecutiv e ones, form base-pairs with the DNA oligomers, the selective scission occu rs at the 3'-side of the middle of these three non-pairing ribonucleotides.