A case of adult moyamoya disease showing progressive angiopathy on cerebral angiography

In moyamoya disease, progression of carotid occlusive lesion in an adult pa tient is very rare. We report a case of adult moyamoya disease with acute a ngiographical stage progression and hemodynamic deterioration. A 56-year-ol d female complaining of left motor weakness visited our department. On MRI, infarct lesion was found in the right white matter. On cerebral angiograph y, occlusive lesions in the bilateral internal carotid arterial siphons and moyamoya vessels were found. The right side was stage V and the left side was stage III. On LMP-SPECT, decreased cerebral hemodynamic reserve of the right cerebral hemisphere was found. In this patient, right STA-MCA anastom osis was performed. After operation, she became possible to walk and discha rged to home. Five months after operation, good collateral formation and im provement of hemodynamic reserve in the right hemisphere were found. Howeve r, on left carotid arteriography, the anterior and middle cerebral arteries were only slightly imaged, and the disease state progressed to stage IV. I n addition, decreased blood flow and hemodynamic reserve were appeared in t he left hemisphere. (C) 1999 Elsevier Science B.V. All rights reserved.