Treating asthma with anti-IgE or anti-IL5

In the last decades, several key mechanisms driving asthma pathophysiooogy have been discovered. These include the role of IgE in allergic disease, an d the role of IL-5 in eosinophilic inflammation. In the last few years, too ls to block each of these have been developed. At this rime, early clinical studies with neutralizing antibodies against both IgE and IL-5 have been p erformed in asthma patients, with promising results, and larger studies are underway. The mechanisms of, and possible role of, both anti-IgE and anti- IL-5 treatment in asthma are discussed in this review article.