We report 2 cases of arachnoid cysts, one with a retrocerebellar and t
he other with a left temporal localization, in which immunohistochemic
al studies had been conducted. The results of the immunohistochemistry
on the presence of carcino-embryonic antigen (CEA) and glial fibrilla
ry acidic protein (GFAP), and of the scanning- and transmission electr
on microscopy revealed the cyst lining to be identical to subdural neu
rothelium. Progesterone receptors were found in the nuclei of cells li
ning the cyst, which also suggests the similarity of the cyst lining t
o arachnoid granulations and meningiomas as derivatives of subdural ne
urothelium, which also possess progesterone receptors.