Effects of cyclosporin A on immune activation markers in patients with active psoriasis

Background: Psoriasis is a T-cell mediated autoimmune disease. The objectiv e of this work was to investigate the presence of cellular and soluble acti vation molecules in the blood of patients with psoriasis, not responding to local treatment and to study the effect of cyclosporin A (CsA) on these ma rkets. Methods: Twenty-seven patients and 30 healthy controls were included in the study. The results were evaluated at baseline and at 15 days, 3, 6 and 12 months following initiation of treatment. Results: We found increase d baseline values of lymphocytes and cells expressing the marker CD3+CD25+, CD54+ (ICAM-1) and CD58+ (LFA-3). Following CsA treatment, a significant d ecrease in the percentage of activated T cells expressing CD3+CD25+ and CD3 +HLA-DR+ was noted at 6 and 12 months. Among the soluble factors studied, i ncreased baseline serum levels of sIL-2R, sCD23 and neopterin were observed . CsA significantly reduced the levels of sIL-2R and IL-12. Conclusion: Alt hough there is evidence for systemic immune activation in psoriasis, sIL-2R is the most consistently increased activation marker, related to the Th1 i mmune response, that may be used as a marker for monitoring disease activit y and response to treatment with CsA in psoriatic patients.