R. Schiel et al., Blood-glucose self-monitoring in insulin treated type 2 diabetes mellitus - A cross-sectional study with an intervention group, DIABETE MET, 25(4), 1999, pp. 334-340
Up to the present there is controversy about blood-glucose self-monitoring
in type 2 diabetes. In 842 insulin-treated type 2 diabetic patients (age 60
.1 +/- 10.9, diabetes duration since diagnosis 126 +/- 7.6 years, relative
HbA1c 1.83 +/- 0.39 % [relative HbA1c = HbAlc/mean normal, HPLC, Diamat(R)]
) a cross-sectional study was conducted to assess blood-glucose self-monito
ring and interactions with quality of diabetes care.
There was a negative correlation (r = -0.17, p < 0.001) between the frequen
cy of blood-glucose self-tests/week and HbA1c. Performing multivariate anal
ysis the most important parameters associated with HbA1c (R-square = 0.10)
were: The frequency of blood-glucose self-tests/week (c = -0.005, p < 0.001
), the insulin-dosage/kg body weight (c = 0.001, p = 0.0032) and the partic
ipation in a 5-day structured treatment and teaching programme for patients
with conventional insulin therapy (5-TTP, c = 0.085, p < 0.0001). Other fa
ctors investigated in the model (age, diabetes duration, number of insulin
injections/day, sex) showed no associations. Performing a sub-group analysi
s in patients older than 60 years (n = 396) parameters associated with HbA1
c (R-square = 0.16) were the participation in a 5-TTP (c = 0.09, p = 0.002)
and the frequency of blood-glucose self-tests/week (c = -0.006, p = 0.0018
) too. In an further subgroup analysis patients (n = 249) were investigated
who have not participated in a 5-TTP. In this cohort there were no correla
tions and no associations between the frequency of blood-glucose self-monit
oring and HbA1c. Then, an intervention was started: 33 out of the 249 patie
nts participated in a 5-TTP. At the time of re-examination 1 year after par
ticipating in the 5-TTP, the relative HbA1c decreased from 1.84 +/- 0.38 %
to 1.61 +/- 0.30 % (p = 0.007) and there was a strong association between t
he frequency of blood-glucose self-tests/week and HbA1c (c = -0.016, p = 0.
0032 R-square 0.25).
Daily blood-glucose self-monitoring was statistically associated with bette
r quality of metabolic control. Participation in a 5-TTP and regularly bloo
d-glucose self-monitoring is mandatory for all insulin-treated patients wit
h type 2 diabetes mellitus.