Impact of body mass on autonomic function in persons with type 2 diabetes

The aim of this study was to investigate the influence of body mass on auto nomic nerve function in persons with type 2 diabetes. Towards this aim we s tudied two groups of diabetic persons. Group 1: n = 30 lean (mean age 57.2 +/- 12.5 years, body mass index (BMI) 22.5 +/- 1.8 kg/m(2)]. Group 2: n = 3 5 overweight and obese (age 52.3 +/- 10.3 years, BMI 28.8 +/- 3.2 kg/m(2)). Autonomic neuropathy (DAN) was assessed using the battery of the five clas sical tests. DAN was diagnosed when at least two of the five tests were abn ormal. Abnormalities of the heart rate based tests were considered as indic ation of parasympathetic and of blood pressure changes as indication of sym pathetic dysfunction. The prevalence rates of DAN were not different betwee n group 2 and group 1 (54.2 and 53.3%, respectively, P = 0.54). The same wa s valid for the rates of parasympathetic and sympathetic dysfunction in the studied groups (51.4 and 53.3% (P = 0.87) in group 2 and 34.2 and 33.3% (P = 0.93) in group 1, respectively). When the values of the arithmetic expre ssion of each single autonomic function test were compared, no significant difference could be shown between the studied groups. In addition, no signi ficant correlation was found between BMI and indices of DAN. These data ind icate that moderate increase of body mass does not affect autonomic functio n in persons with type 2 diabetes. (C) 1999 Elsevier Science Ireland Ltd. A ll rights reserved.