The effect of insulin sensitizer, troglitazone, on lipoprotein lipase massin preheparin serum

Lipoprotein lipase mass exists in preheparin serum, even though the activit y is scarcely found. The implication of this is unclear. We studied the eff ect of an insulin sensitizer, troglitazone, on this preheparin serum lipopr otein lipase mass (preheparin LPL mass) in non-insulin-dependent diabetes m ellitus (NIDDM) patients as well as on serum lipid levels and low density l ipoproteins (LDL) particle size. Thirty-one NIDDM patients with poor contro l were administered troglitazone 400 mg/day. Hemoglobin A1c had significant ly decreased (13%, P < 0.001) 2 months later. Preheparin LPL mass had gradu ally increased and a 69% increase (P < 0.01) was observed 4 months later. T riglyceride significantly decreased (23%, P < 0.01) and high density lipopr otein-cholesterol increased (10%, P < 0.01), whereas total cholesterol and LDL levels did not change 4 months later. The size of LDL increased signifi cantly (P < 0.01). These results were consistent with the idea that prehepa rin LPL mass might be relating to the insulin sensitivity enhanced by trogl itazone, as well as LDL particle size, (C) 1999 Elsevier Science Ireland Lt d. All rights reserved.