Gas-chromatographic enantiomer separation of proteinogenic amino acid derivatives: Comparison of Chirasil-val and Chirasil-gamma-dex used as chiral stationary phases

The polymeric chiral stationary phases (CSPs) Chirasil-Val (polysiloxane-li nked N-propanoyl-L-valine tert-butyl amide) and Chirasil-gamma-Dex (polysil oxane-linked (3-O-butanoyl-2,6-di-O-n-pentyl)-gamma-cyclodextrin) are compa red with regard to their advantages and disadvantages in the gas-chromatogr aphic enantiomer separation of proteinogenic amino acid derivatives (triflu oroacetyl or pentafluoropropanoyl amides, ethyl or 2-proyyl esters). Each C SP shows a distinct behaviour according to thermal stability and enantiosel ectivity towards the amino acid derivatives resulting in different elution orders. Some attempts are made to combine the advantages of both CSPs.