Coenzyme Q(10) in health and disease

The literature concerning the importance of coenzyme Qt, in health and dise ase has been reviewed. Usual dietary intake together with normal in vivo sy nthesis seems to fulfil the demands for Q(10) in healthy individuals. The i mportance of Q(10) supplementation for general health has not been investig ated in controlled experiments. The literature allows no firm conclusions a bout the significance of Q(10) in physical activity. In different cardiovas cular diseases, including cardiomyopathy, relatively low levels of Q(10) in myocardial tissue have been reported. Positive clinical and haemodynamic e ffects of oral Q(10) supplementation have been observed in double-blind tri als, especially in chronic heart failure. These effects should be further e xamined. No important adverse effects have been reported from experiments u sing daily supplements of up to 200 mg Q(10) for 6-12 months and 100 mg dai ly for up to 6y.