Dinucleotide repeat polymorphisms within the Flt-1 gene in minimal change nephropathy

Authors
Parry, RG Gillespie, KM Clark, AGB Mathieson, PW
Citation
Rg. Parry et al., Dinucleotide repeat polymorphisms within the Flt-1 gene in minimal change nephropathy, EUR J IMM, 26(5), 1999, pp. 321-323
Citations number
13
Categorie Soggetti
Immunology
Journal title
EUROPEAN JOURNAL OF IMMUNOGENETICS
ISSN journal
09607420 → ACNP
Volume
26
Issue
5
Year of publication
1999
Pages
321 - 323
Database
ISI
SICI code
0960-7420(199910)26:5<321:DRPWTF>2.0.ZU;2-R
Abstract
Dysregulation of Flt-1, a major receptor for vascular permeability factor ( VPF), may provide a mechanism for the development of proteinuria in minimal change nephropathy (MCN). The gene for Flt-1 has a polymorphic dinucleotid e repeat. We have demonstrated an 88% predominance of one allele and an 80% rate of homozygosity for this polymorphism with no association with MCN.