Preoperative high dose methylprednisolone improves patients outcome after abdominal surgery

Objective: To assess the effect of preoperative high dose methylprednisolon e on stress response and outcome. Design: Randomised, placebo-controlled, double-blind study. Setting: University hospital, Germany. Subjects: 20 patients listed for abdominal surgery of whom 10 had major int ra-abdominal interventions and 10 had incisional hernias repaired. Interventions: Methylprednisolone 30 mg/kg (100 mi) was given by slow intra venous infusion 90-60 minutes before operation. The control group received the same volume of sodium chloride. Main outcome measures: Speed of convalescence, degree of fatigue, amount of pain, consumption of analgesics, breathing capacity, and hospital stay, as well as humoral and cellular mediators of the stress response. Results: Methylprednisolone significantly improved criteria of postoperativ e recovery, fatigue by 47%, (day 1), convalescence by about 45% (days 1-3), and breathing capacity (FEV1) between 47% and 29% (days 5, 7) (p < 0.05, A NOVA), and led to a significant reduction of median hospital stay of 4.5 da ys. C-reactive protein concentration was significantly decreased (by 46% on day 3) and T-cell activation was suppressed (day 1). Conclusion: Outcome of the patients after conventional abdominal surgery is substantially improved by preoperative high dose methylprednisolone. This effect is more pronounced in patients having major operations.