PHYSIOLOGICAL BACKGROUND OF ENURESIS TYPE-I - A PRELIMINARY-REPORT

The physiological background of enuresis Type I, which is due to a mil d arousal dysfunction, has been investigated in two studies, one in ra ts and one in children with Type I enuresis. The results of these inve stigations suggest that in this type of enuresis, the fundamental arou sal function following bladder distension, due to an arousal centre li ke the locus coeruleus and its network, is normal. In contrast, the pr ocess of multiplying the transient connection from light sleep to comp lete awakening, which probably relies upon functions of the thalamus a nd the further upper centrums, was thought to be abnormal.