GENETIC-FACTORS AS PREDICTORS FOR DESMOPRESSIN TREATMENT SUCCESS

The significance of a positive family history in predicting responsive ness to desmopressin (DDAVP(R)) treatment was evaluated in 71 children with nocturnal enuresis. A good response to treatment was recorded in 91% of those children with a positive family history compared with on ly 7% of those with a negative family history. A review of the publish ed literature further supports the predictive value of a positive fami ly history and also confirms the importance of a broad definition for family history-including persistent nocturia. The importance of defini ng the family history is also discussed in terms of response to some o ther therapies for nocturnal enuresis.