Tazarotene increases the antipsoriatic effect of dithranol in chronic psoriasis

We examined wether it is possible to increase the antipsoriatic action by c ombining dithranol with a retinoid (tazarotene). In a randomized, open, pro spective study with 50 psoriatic patients (22 females, 28 males, PASI>10) t he antipsoriatic effectiveness of dithranol monotherapy to was compared com bined therapy with dithranol and retinoid. The combination dithranol/retino id (collective, reduction of the PASI from 17,2 to 2,8) revealed a signific antly faster healing than the dithranol monotherapy (collective 1,reduction of the PASI from 18,5 to 4,8). The irritation of the combination therapy a s evaluated with clinical score and laser doppler imaging was increased. An ti-psoriatic effectiveness of dithranol can be increased by combining it wi th tazarotene.