ASSOCIATIONS AMONG URODYNAMIC FINDINGS AND SYMPTOMS IN WOMEN ENROLLEDIN THE INTERSTITIAL CYSTITIS DATA-BASE (ICDB) STUDY

Objectives. The goal of this study was to correlate the cystometric fi ndings with the presenting symptoms of the 388 women enrolled in the N IH/NIDDK-funded Interstitial Cystitis Data Base (ICDB) Study as of Dec ember 31, 1995. Methods. All patients underwent a complete history and physical and completed standardized questionnaires to assess voiding symptoms and quality of life (QOL). A 3-day voiding log was also obtai ned, followed by a baseline urodynamic exam. All results are expressed as mean values tl standard deviation, and all reported correlations w ere significant. Results. A correlation was seen between reported dayt ime, nighttime, and 24-hour frequency, and both volume at first sensat ion to void (VFSV) and maximal cystometric capacity (VMCC). Patients w ith constant severe urgency had smaller VFSV, 63 +/- 59 mL versus 108 +/- 90 mL, and lower VMCC, 163 +/- 102 mL versus 288 +/- 135 mL, than patients without the complaint. A negative trend was seen for both VFS V and VMCC versus the global symptom severity. An inverse trend was se en between minimal and maximal pain scores over the 4 weeks before the exam and VMCC. (No correlation existed between current pain noted dur ing baseline screening visits and VFSV or VMCC.) No urodynamics correl ates were seen with global measures of body pain and global health. Un inhibited detrusor contractions (UDCs) were seen in 56 of 384 patients (14.6%). A positive correlation was seen between urgency symptoms and the presence of UDCs. Correlations between the VFSV and the VMCC were made with both the average voided volume (AW) and the average maximal voided volume (AMW) as determined by a 3-day voiding log. Significant positive correlations were seen with each pair-wise comparison (P=0.0 01). Conclusion. These findings confirm that subjective measurements o f symptoms associated with interstitial cystitis can be confirmed obje ctively with urodynamic studies. (C) 1997 by Elsevier, Science Inc.