Effect of aqueous or ethanol extract of coffee pulp on reproduction and biochemical constituents in rat

The present study assessed the effect of oral administration of aqueous or ethanolic extract of coffee pulp 2 g/kg/day far 35, 65 or 95 days to male r ats. There was no morbidity or mortality in rats given 1, 2, 4, 8 or 16 g/k g of aqueous or ethanolic extract of coffee pulp suggesting the absence of toxicity or even lethality. Compared to controls, there was no difference i n the spermatogenesis, blood plasma testosterone concentration, fertility a nd number of pups born in the coffee pulp extract - treated male rats. The concentration of glucose, total protein, aspartate amino transferase (AST), alanine amino transferase (ALT), blood urea nitrogen (BUN), creatinine, ph osphorus, calcium sodium, potassium and haematological parameters like whit e blood cells (WBC), red blood cells (RBC) and haemoglobin (Hb) and body we ight were similar between control and coffee pulp extract-treated rats. At the tested dose, the coffee pulp extracts did not exert any effect.