Cell death of human polymorphonuclear neutrophils induced by a Pseudomonasaeruginosa cystic fibrosis isolate requires a functional type III secretion system

Citation
D. Dacheux et al., Cell death of human polymorphonuclear neutrophils induced by a Pseudomonasaeruginosa cystic fibrosis isolate requires a functional type III secretion system, INFEC IMMUN, 67(11), 1999, pp. 6164-6167
Citations number
32
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
67
Issue
11
Year of publication
1999
Pages
6164 - 6167
Database
ISI
SICI code
0019-9567(199911)67:11<6164:CDOHPN>2.0.ZU;2-R
Abstract
With a coincubation model incorporating Pseudomonas aeruginosa and human po lymorphonuclear neutrophils (PMNs), a cystic fibrosis (CF) P. aeruiginosa i solate has been shown to resist the bactericidal action of PMNs and to indu ce their cellular death. An isogenic mutant of this CF isolate in which the type III secretion system was rendered nonfunctional was unable to induce cellular death of PMNs.