Cell death of human polymorphonuclear neutrophils induced by a Pseudomonasaeruginosa cystic fibrosis isolate requires a functional type III secretion system
D. Dacheux et al., Cell death of human polymorphonuclear neutrophils induced by a Pseudomonasaeruginosa cystic fibrosis isolate requires a functional type III secretion system, INFEC IMMUN, 67(11), 1999, pp. 6164-6167
With a coincubation model incorporating Pseudomonas aeruginosa and human po
lymorphonuclear neutrophils (PMNs), a cystic fibrosis (CF) P. aeruiginosa i
solate has been shown to resist the bactericidal action of PMNs and to indu
ce their cellular death. An isogenic mutant of this CF isolate in which the
type III secretion system was rendered nonfunctional was unable to induce
cellular death of PMNs.