Detection of donor- and product-specific parameters in plasmapheresis

Background: The current method of determining donor- and product-relevant p arameters from donor serum and plasma do not only involve the safety-releva nt risk of confusing the individual samples - obtained directly from the pl asma donor or from the plasma product - but also brings up ethical and econ omic considerations. Material and Methods: This trial is based on the deter mination and comparison of the parameters of total protein, IgG, ALAT, albu min, and creatinine, obtained either from the usual serum or from plasma sa mples which have been collected from mechanically obtained plasma. Results and Conclusions: This trial showed that both parameter groups can be determ ined easily and without alteration of safety-relevant factors by using the serum or plasma collected by plasmapheresis. The anticoagulant-related plas ma dilution can be adjusted by means of the regression functions provided s o that all parameters may be correlated with the serum values used so far.