H. Szymanska et al., Genetics of susceptibility to radiation-induced lymphomas, leukemias and lung tumors studied in recombinant congenic strains, INT J CANC, 83(5), 1999, pp. 674-678
The genetic control of susceptibility to radiation-induced tumors in mice h
as been tested using the series of 20 CcS/Dem (CcS) Recombinant Congenic St
rains, each carrying a different random set of 12.5% of genes of the resist
ant strain STS/A (STS) on the genetic background of the susceptible strain
BALB/cHeA (BALB/c), Two classes of tumors were frequently observed: tumors
of the haematopoietic system (lymphomas, myelocytic leukemias) and lung tum
ors. The results indicate that the genes controlling various aspects of tum
or development were segregated in the CcS strain series. Large inter-strain
differences were observed in the incidence of lung tumors. With lymphomas
and leukemias, we not only observed strain differences in the incidence of
tumors and in the latency of their development but also in the type of tumo
rs (T- vs, B-cell lymphomas, myelocytic tumors) and in the frequency of the
ir localized or disseminated (leukemic) form. Surprisingly, the myelocytic
tumors, which occur very rarely or not at all in the parental strains BALB/
c and STS or in their crosses, developed with high frequency in one of the
CcS strains (CcS-2):, indicating a unique combination of genes in this stra
in, which facilitates the development of myelocytic tumors. The effect of t
hese genes is suppressed in the genetic composition of the parental strains
. Tests of crosses of the resistant-strain CcS-13 with BALB/c indicated a s
uggestive linkage of a susceptibility gene for lymphomas to chromosome 5, T
hese tests of the CcS strains illustrate the genetic complexity of the cont
rol of radiation-induced tumors in mice and suitability of these model syst
ems to study their different facets, (C) 1999 Wiley-Liss, Inc.