BIOSYNTHESIS OF FLUOROACETATE AND 4-FLUOROTHREONINE BY STREPTOMYCES-CATTLEYA - THE STEREOCHEMICAL PROCESSING OF GLYCEROL

Authors
NIESCHALK J HAMILTON JTG MURPHY CD HARPER DB OHAGAN D
Citation
J. Nieschalk et al., BIOSYNTHESIS OF FLUOROACETATE AND 4-FLUOROTHREONINE BY STREPTOMYCES-CATTLEYA - THE STEREOCHEMICAL PROCESSING OF GLYCEROL, Chemical communications, (8), 1997, pp. 799-800
Citations number
9
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
8
Year of publication
1997
Pages
799 - 800
Database
ISI
SICI code
1359-7345(1997):8<799:BOFA4B>2.0.ZU;2-4
Abstract
When both (2R)-[1-H-2(2)]- and (2S)-[1-H-2(2)]-glycerol are incubated with resting cell suspensions of S. cattleya, only the 2R-enantiomer l abels the fluoromethyl groups of fluoroacetate and 4-fluorothreonine, with retention of both deuterium atoms, placing metabolic and mechanis tic limitations on the process of biological fluorination.