Y. Fukuma et al., Correlation between atrial natriuretic peptide and baroreflex sensitivity in patients with congestive heart failure, JPN CIRC J, 63(11), 1999, pp. 893-899
Citations number
49
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
The aim of this study was to investigate the relationship between barorefle
x sensitivity (BRS) and humoral factors in patients with congestive heart f
ailure (CHF). BRS was assessed by the phenylephrine method in 16 patients w
ith CHF and in 13 healthy controls. The CHF group was subdivided into 2 gro
ups according to BRS (group A: <6 ms/mmHg, n = 9; group B: greater than or
equal to 6 ms/mmHg, n = 7). BRS was markedly depressed in CHF than in the c
ontrols (4.8 +/- 2.0 vs 8.3 +/- 3.6 ms/mmHg, p < 0.01), and lower in group
A than group B (3.3 +/- 1.3 vs 6.7 +/- 0.6 ms/mmHg, p < 0.01). The plasma h
uman atrial natriuretic peptide (h-ANP) level in group A was significantly
higher than in group B (54.6 +/- 27.6 vs 18.0 +/- 7.4 pg/ml, p < 0.01), and
a significant inverse correlation was observed between plasma h-ANP and BR
S (r = -0.635, p < 0.01). However, then were no significant differences bet
ween the 2 groups in plasma catecholamine concentration, plasma renin activ
ity and cardiac function by echocardiogram. These findings suggest that the
elevation of endogenous ANP may also serve to compensate for impaired BRS
in patients with CHF, in addition to its principal actions, such as diuresi
s and vasodilation.