ELEVATED SERUM LEVELS OF S100 AND SURVIVAL IN METASTATIC MALIGNANT-MELANOMA

Current reports suggest serum S100 as a prognostic marker for disease progression in advanced malignant melanoma. In this study, we assessed serum levels of S100 and multiple clinical factors in relation to ove rall survival in 99 patients with metastatic malignant melanoma seen a t our institution between May 1990 and April 1996. For statistical ana lysis, we used both univariate and multivariate Cox proportional-hazar ds models. Elevated serum levels of S100 correlated with poor outcome in metastatic malignant melanoma (P < 0.0001), univariate analysis). U pon multivariate analysis, however, S100 added no information to known clinical prognostic parameters.