SUSCEPTIBILITY TO ENDOMETRIAL CANCER - INFLUENCE OF ALLELISM AT P53, GLUTATHIONE-S-TRANSFERASE (GSTM1 AND GSTT1) AND CYTOCHROME-P-450 (CYP1A1) LOCI

Authors
ESTELLER M GARCIA A MARTINEZPALONES JM XERCAVINS J REVENTOS J
Citation
M. Esteller et al., SUSCEPTIBILITY TO ENDOMETRIAL CANCER - INFLUENCE OF ALLELISM AT P53, GLUTATHIONE-S-TRANSFERASE (GSTM1 AND GSTT1) AND CYTOCHROME-P-450 (CYP1A1) LOCI, British Journal of Cancer, 75(9), 1997, pp. 1385-1388
Citations number
25
Categorie Soggetti
Oncology
Journal title
British Journal of Cancer → ACNP
ISSN journal
00070920
Volume
75
Issue
9
Year of publication
1997
Pages
1385 - 1388
Database
ISI
SICI code
0007-0920(1997)75:9<1385:STEC-I>2.0.ZU;2-C
Abstract
A case-control study was designed to identify associations between pol ymorphisms at p53, cytochrome P-450 (CYP1A1) and glutathione-S-transfe rases and endometrial cancer susceptibility. Among all polymorphisms a nalysed, an insertional variant in p53 (P53PIN3) and two polymorphisms in the 3'-end and exon 7 of CYP1A1 showed significant association wit h enhanced endometrial cancer risk.