Critical overview: Adverse cutaneous reactions to psychotropic medications

Background: Adverse cutaneous reactions (ACRs) are common, potentially life -threatening or symptomatically and cosmetically unappealing side effects o f psychotropic drugs. Data Sources: A MEDLINE search of the literature was employed to cite the a ssociation of various psychotropic drugs with specific cutaneous reactions. Data Synthesis: In addition to the common exanthematous eruption, we explor e several serious reactions including erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria, angioedema, anaphylaxis, h ypersensitivity syndrome, hypersensitivity vasculitis, erythroderma, and dr ug-induced lupus erythematosus. Other side effects such as alopecia, pigmen tary disorders, photosensitivity, lichenoid lesions, fixed drug eruptions, and psoriasiform, acneiform, and seborrheic eruptions are discussed. Attent ion is paid to the morphology and distribution, systemic findings, diagnosi s, and treatment of these conditions. Conclusion: Awareness of ACRs will allow psychiatrists to deter their conti nuation or recurrence, educate patients who have them, and diagnose serious instances of them.