Biopharmaceutics of transmucosal peptide and protein drug administration: role of transport mechanisms with a focus on the involvement of PepT1

Non-invasive delivery of peptide and protein drugs will soon become a reali ty. This is due partly to a better understanding of the endogenous transpor t mechanisms, including paracellular transport, endocytosis, and carrier-me diated transport of mucosal routes of peptide and protein drug administrati on. This paper focuses on work related to the elucidation of structure-func tion, intracellular trafficking, and regulation of the intestinal dipeptide transporter, PepT1. (C) 1999 Elsevier Science B.V. All rights reserved.