Modelling of the amperometric biosensors based on carbon paste electrodes e
ncrusted with a single heterogeneous microreactor is analyzed. The microrea
ctor was constructed from CPC-silica carrier and was loaded with glucose ox
idase. The model is based on non-stationary diffusion-reaction equations co
ntaining a non-linear term related to the enzymatic reaction. A homogenizat
ion process having an effective algorithm for the digital modelling of the
operation of the microreactor is proposed. The influence of the size, geome
trical form, and the position of a microreactor on the operation of biosens
ors are investigated.