Novel metallocenic compounds as antimalarial agents. Study of the positionof ferrocene in chloroquine

Authors
Biot, C Delhaes, L Abessolo, H Domarle, O Maciejewski, LA Mortuaire, M Delcourt, P Deloron, P Camus, D Dive, D Brocard, JS
Citation
C. Biot et al., Novel metallocenic compounds as antimalarial agents. Study of the positionof ferrocene in chloroquine, J ORGMET CH, 589(1), 1999, pp. 59-65
Citations number
30
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF ORGANOMETALLIC CHEMISTRY
ISSN journal
0022328X → ACNP
Volume
589
Issue
1
Year of publication
1999
Pages
59 - 65
Database
ISI
SICI code
0022-328X(19991030)589:1<59:NMCAAA>2.0.ZU;2-2
Abstract
The synthesis, characterization and antimalarial activity of two new ferroc ene-chloroquine compounds are reported. One of them, 7-chloro-4-N-[(4-N'-et hyl-N'-ferrocenylmethyl)ammonio-1-methylbutylamino]quinolin-1-ium bi-tartra te (2) showed very promising antimalarial activity in vivo on mice infected with Plasmodium berghei N. and Plasmodium yoelii NS. and in vitro against chloroquine resistant-strains of Plasmodium falciparum. (C) 1999 Elsevier S cience S.A. All rights reserved.