Inhibition and photo-deinhibition of glutathione (S)-transferase activity by an organometallic complex: (S)-[3-CpFe(CO)(2)(eta(1)-N-succinimidato)]glutathione

Authors
Salmain, M Jaouen, G Rudolf, B Zakrzewski, J
Citation
M. Salmain et al., Inhibition and photo-deinhibition of glutathione (S)-transferase activity by an organometallic complex: (S)-[3-CpFe(CO)(2)(eta(1)-N-succinimidato)]glutathione, J ORGMET CH, 589(1), 1999, pp. 98-102
Citations number
17
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF ORGANOMETALLIC CHEMISTRY
ISSN journal
0022328X → ACNP
Volume
589
Issue
1
Year of publication
1999
Pages
98 - 102
Database
ISI
SICI code
0022-328X(19991030)589:1<98:IAPOG(>2.0.ZU;2-4
Abstract
The bioorganometallic complex (S)-[3-CpFe(CO)(2)(eta(1)-N-succinimidato)]gl utathione 1 resulting from the reaction of glutathione with (eta(5)-Cp)Fe(C O)(2)(eta(1)-N-maleimidato) is shown to inhibit in a competitive manner the enzymatic activity of glutathione (S)-transferase. Moreover, when the Fp f ragment is removed by photochemical means, the resulting compound 2 loses t his property, which thus appears to be due to the presence of the organomet allic moiety. (C) 1999 Elsevier Science S.A. All rights reserved.