Cutaneous CD8+T cell infiltrates in advanced HIV infection

Background: Aggressive non-Hodgkin's lymphomas are common among patients in fected with HIV: Although such lymphomas are mostly of the B-cell type, var ious cases of cutaneous T-cell lymphoma (CTCL) have also been reported. Rec ent reports suggest that some HIV-related lymphoproliferative conditions ma y not be clonal processes, but polyclonal lymphoid proliferations. Objective: We reviewed our experience with HIV patients seen at the dermato logy clinics for possible CTCL. Methods: A retrospective study was performed to evaluate clinical, laborato ry, and histologic findings of HIV-infected patients with atypical T-cell c utaneous infiltrates. Results: We observed 9 patients with advanced HN infection and a cutaneous eruption characterized by a dense infiltrate of lymphocytes resembling myco sis fungoides histopathologically: but composed of CD8(+) cells. Although c lonality was not identified in any of the 6 cases tested, 3 patients had si milar CD8(+) infiltrates involving lymph nodes or bone marrow Of the 9 pati ents, 8 died of AIDS wasting syndrome or infections in less than 1 year. Conclusion: Cutaneous and systemic infiltrates with polyclonal CD8 T lympho cytes can be seen in patients with advanced HIV infection and profound CD4 lymphopenia. The clinical presentation may resemble CTCL and is associated with a poor outcome.