Early dexamethasone treatment in preterm infants treated with surfactant: A double blind controlled trial

The objective of the study was to test the hypothesis that early postnatal dexamethasone administration (days 1-5) in preterm infants with respiratory distress syndrome would improve acute respiratory status and therefore dec rease long-term neonatal morbidity. This was a prospective, blind randomize d controlled trial. Eligible neonates were preterm infants with birthweight less than or equal to 1500 g who developed respiratory distress syndrome r equiring mechanical ventilation and surfactant. A 5-day course of dexametha sone or placebo was initiated within the first 6 h after birth. The startin g dose of dexamethasone was 0.5 mg/kg/day and it was tapered progressively. Results were analysed with t-test chi(2), Wilcoxon test, and ANOVA. Twenty -nine infants (n = 15 of early dexamethasone and n = 14 of placebo group) f ulfilled the inclusion criteria. The dexamethasone group exhibited a signif icant improvement in arterial to alveolar oxygen ratio only between postnat al days 2 and 5 (p = 0.02). This initial improvement was not associated wit h long-term benefits. Infants who received dexamethasone had increased syst olic blood pressure (p = 0.0001), diastolic blood pressure (p = 0.001), blo od sugar (P = 0.02, serum urea (p = 0.03), and creatinine level (p = 0.02), All these side-effects were resolved by postnatal day 7. We concluded that a 5-day course of early postnatal dexamethasone was associated with only a transient improvement in oxygenation with no long-term benefits. Side-effe cts were more common in the dexamethasone group.